CBI five: The Brain is a 2022 Indian Malayalam-language mystery mystery film directed by means of K. Madhu and written by means of S. N. Swamy. The movie stars Mammootty reprising his position as Central Bureau of Investigation (CBI) officer Sethurama Iyer in conjunction with an ensemble cast. It is the fifth installment of CBI movie collection. The movie become released in theatres on May 1st, 2022. It changed into later released on the OTT platform Netflix on June 12th, 2022.